"The price of greatness is responsibility." Sir Winston Churchill


Search the IBPA



Top Menu

Menu Sidebar

IBPA Issues
About IBPA
IBPA Constitution
FAQ-s
IBPA Events
Individual Membership
Institutional Membership
IBPA Forums / Groups
Cooperation with IBPA
Links

Publications
IBPA Careers Newsletter
Past Issues
Industry Publications
Promote Yourself within the Industry
Submit Your Article

Career Center: Employers
Job Posting
Free Resume Database
Volunteers Database

Career Center: Job Seekers
Now Hiring
Submit Resume
Career Training
Nurses Careers in Biopharm
Scholarship Programs
Internship Programs
Resume Editing & Interview Coaching
Volunteer for the Industry
Download IBPA Career Info Brochure

Industry Directories and Listings
Pharmaceutical Companies
Contract Research Organizations
Professional Associations
Recruiters and Staffing Agencies
Clinical Research Centers
Consulting Companies
Education & Training Institutions
Jobs and Resume Searching Directories
Research and Development Companies
Industry Service Providers
List Your Company

Investor's Center
Offers
Calls

Contact IBPA
USAChapter
Canadian Chapter
European Chapter
Asian Chapter

Start Your Career in Biotech with IBPA Scholarship Programs
Untitled Document



Subscribe to our "Careers in the Biopharmaceutical Industry" newsletter:

Name*:

Email*:

City:

Country:

Phone:

To unsubscribe, click here

 

 

Death

From Wikipedia, the free encyclopedia.

 
For other uses, see Death (disambiguation).

Death is the cessation of physical life in a living organism or the state of the organism after that event.

Contents

[hide]

[edit]

 

Interpretations of "Death"

In almost all societies, death has one or several symbols associated with it. Common symbols of death in Western cultures include the grim reaper and the color black; conversely, in certain Eastern cultures, the color white is considered symbolic of death. The grave is a metonym for death.

Biologically, death can occur to wholes, to parts of wholes, or to both. For example, it is possible for individual cells and even organs to die, and yet for the organism as a whole to continue to live; many individual cells can live for only a short time, and so most of an organism's cells are continually dying and being replaced by new ones.

Conversely, when organisms die their cells can live for some time afterward. Organs, for instance, can be removed for transplantation. They must be removed and transplanted quickly, or they too will soon die without the support of their host. Rarely, cell cultures can be "immortal" as in the case of Henrietta Lacks' HeLa cell line.

Fingernails and hair appear to grow after a person's death, as, due to bodily dehydration, the flesh pulls away from the hair and nails. In ancient times, this led to confusion about whether a body was actually dead, and added to the myth of vampires.

Irreversibility is often cited as a key feature of death. By definition, a dead organism cannot be brought back to life; if it were to be, that would indicate that it had never been dead. Nonetheless, many people do not believe that death is necessarily irreversible; thus some have a religious belief in bodily or spiritual resurrection, while others have hope for the eventual prospects of cryonics or other technological means of reversing what is currently thought of as death.

It has been hypothesized that a limited lifespan is a consequence of evolution not selecting for extreme longevity in most species, as evolutionary selection only need apply to the organism up to the point of reproduction; after that, except for caring for kin, the continued existence of an individual can have little effect on the survival of its gene line. A common assumption is that the Second Law of Thermodynamics dictates that all complex systems must eventually deteriorate, so it is not likely that any species could ever be immortal. However, this aspect of the Second Law of Thermodynamics only applies to closed systems, which a living organism obviously is not.

[edit]

 

Ways of Defining Human Death: Medical, Religious, and Legal

Human death can be defined by three dramatically different but overlapping domains: medical, religious, and legal. These different domains and their imporance have evolved over time and can vary from person to person. So when talking about death, it is important to differentiate which domain we are speaking of and to have a general understanding of how each defines death.

There are various ways of defining medical death. Early in western culture, death was connected to the heart first and then later the lungs. When these stopped working, a person was dead. It was sometime later that the brain came into the equation. One of the first series tests for brain death was the Harvard brain test. The test consisted of squirting ice cold water into the patient's ear. If they screamed, they were still alive. Another test involved poking the patients foot with a pin and looking for similar results. In 1963 a device called an electroencephalogram (EEG) was invented that could very accurately measure the electrical output of the brain. The test showed that when the machine registered zero electrical output from a person's brain (also known as a flat EEG) for 36 hours, the patient could be considered dead. We now know that a person can continue to be medically alive until their brain stem dies. Patients in a persistent vegetative state still have an active brain stem.

Legally a person can be pronounced dead in three different ways. By far the most common pronoucer of death is a medical doctor or a doctor of ostyopathy. Second would be a coroner or a state medical examiner. A coroner is a an elected offical who is most often also a mortician or has had some experience in police work. Hospice workers can also be deputised as coroners. State medical examiner, however, is an appointed position. The third way a person can be pronounced legal dead is by the courts. After a person has disappeared for sometime, the courts will pronounce them dead so their property can be distributed in the appropriate way. A death certificate is a legal document that contains how, when, and why a person died and who pronounced them dead.

In religous terms, a person is dead when the soul or essence has left the body. The question would be then, when has the soul left the body. Various tests have been created to test when the soul has left the body, incluiding weighing the body before and after death. See the section below for concepts on what happens to a person after they die.

[edit]

 

When is a person dead?

How can we identify the exact moment at which death has occurred? This seems important, because identifying that moment would allow us to put the correct time on death certificates, make sure that the deceased's will is enacted only after the deceased is truly deceased, and, in general, guide us in emotional behavior regarding death. In particular, identifying the moment of death is important in cases of transplantation, as organs must be harvested as quickly as possible after death.

Historically, attempts to define the exact moment of death have been problematic. Death was once defined as the cessation of heartbeat (cardiac arrest) and of breathing, for example, but the development of CPR and early defibrillation posed a challenge: either the definition of death was incorrect, or techniques had been discovered that really allowed one to reverse death (because, in some cases, breathing and heartbeat can be restarted). Generally, the first option was chosen. (Today this definition of death is known as "clinical death".)

Today, where a definition of the moment of death is required, we usually turn to "brain death" or "biological death": people are considered dead when the electrical activity in their brain ceases (cf. persistent vegetative state). It is presumed that a stoppage of electrical activity indicates the end of consciousness.

Brain activity is a necessary condition to legal personhood, and, perhaps with the exception of the fetus, it is a sufficient condition for legal personhood. "It appears that once brain death has been determined … no criminal or civil liability will result from disconnecting the life-support devices." Dority v. Superior Court of San Bernardino County, 193 Cal.Rptr. 288, 291 (1983)

However, those maintaining that only the neo-cortex of the brain is necessary for consciousness sometimes argue that only electrical activity there should be considered when defining death. In most places the more conservative definition of death (cessation of electrical activity in the whole brain, as opposed to just in the neo-cortex) has been adopted (for example the Uniform Determination Of Death Act in the United States). The recent case of Terri Schiavo brought the question of brain-death and artificial sustainment to the front of American politics. However, in all cases the common cause of death is anoxia.

Even in these cases, the determination of death can be difficult. EEGs can detect spurious electrical impulses when none exists, while there have been cases in which electrical activity in a living brain has been too low for EEGs to detect. Because of this, hospitals often have elaborate protocols for determining death involving EEGs at widely separated intervals.

Medical history contains many anecdotal references to people being declared dead by physicians and coming back to life, sometimes days later in their own coffin or when embalming procedures are about to get underway. Stories of people actually being buried alive (which must assume embalming has not occurred) led at least one inventor in the early 20th century to design an alarm system that could be activated from within the coffin.

Because of the difficulties in determining death, under most emergency protocols, a first responder is not authorized to pronounce a patient dead; some EMT training manuals, for example, specifically state that a person is not to be assumed dead unless there are clear and obvious indications that death has occurred, such as mortal decapitation, rigor mortis (the stiffening of the body), dependent lividity (blood pooling in the lowest part of the body), decomposition, or incineration. If there is any possibility of life and in the absence of a do not resuscitate order, emergency workers must begin rescue and not end it until a patient has been brought to a hospital to be examined by a physician. This frequently leads to situation of a patient being pronounced dead on arrival.

It is also possible that death does not occur at a particular moment, but unfolds as a process over a period of time. Under this definition, the term "exact moment of death" loses meaning.

[edit]

 

Cause of death in the United States

The cause of death in certain area and certain group of ages are different according to area and each group. In 2002 in the U.S. the top 10 causes of death were:

[edit]

 

Other notable causes of death in the United States (2002)

  • Intentional Abortion: 1,293,000
    • Note that there is much debate as to when a fetus is declared a "human." The death of a human zygote — a one-celled combination of a sperm and an egg — is counted by some as the death of a human, and by others as simply the death of a cell. This number would apparently include abortions to save the life of the mother, abortions of obviously highly defective fetuses, and abortions of fetuses unlikely to reach term.

Statistical data from: U.S. Department of Health & Human Services Death Penalty Information Center National Right To Life, and The Alan Guttmacher Institute

[edit]

 

What happens to humans after death?

The second question is of what, apart from the cessation of metabolism and the onset of physiological processes of decay, happens, especially to humans, during and after death (or "once dead", thinking of death as a permanent state). In particular, there is the question of what becomes of consciousness or the soul. Such questions are of long standing, and belief in an afterlife (such as an underworld), or in reincarnation, are common and ancient. The rational belief that any and all consciousness ceases to exist at death, and that death ("after-life") itself is ultimately the exact same experience as prior to conception ("before life"), is common in atheism/agnosticism. Conversely, religious belief in and information about an afterlife is a consolation in connection with the death of a beloved one or the prospect of one's own death. On the other hand, fear of hell or other negative consequences may make death worse. Human contemplation about death is an important motivation for the development of organized religion.

Traditions exist across most cultures to mourn the death of loved ones. Many archaeologists feel that the careful burials among Homo neanderthalensis, where ochre ornamented bodies were laid in carefully dug graves, is evidence of ritualised burial. This may indicate early religious belief which, furthermore, might include a concept of an afterlife.

[edit]

 

Physiological consequences of human death

For the human body, the physiological consequences of death follow a recognized sequence through early changes into bloating, then decay to changes after decay and finally skeletal remains.

The changes in the immediate post-death stage have received the most attention for two reasons—firstly it is the stage mostly likely to be seen by the living and secondly because of the research of forensics in potential crimes.

Soon after death (15–120 minutes depending on various factors), the body begins to cool (algor mortis), becomes pallid (pallor mortis), and internal sphincter muscles relax, leading to the release of urine, feces, and stomach contents if the body is moved. The blood moves to pool in the lowest parts of the body, livor mortis (dependent lividity), within 30 minutes and then begins to coagulate. The body experiences muscle stiffening (rigor mortis) which peaks at around 12 hours after death and is gone in another 24, depending on temperature. Within a day, the body starts to show signs of decomposition (decay), both autolytic changes and from 'attacking' organisms—bacteria, fungi, insects, mammalian scavengers, etc. Internally, the body structures begin to collapse, the skin loses integration with the underlying tissues, and bacterial action creates gases which cause bloating and swelling. The rate of decay is enormously variable; a body can be reduced to skeletal remains in days, or remain largely intact for thousands of years.

In most cultures, before the onset of significant decay, the body undergoes ritual disposal, usually either cremated or deposited in a tomb, often a hole in the earth called a grave, but also in a sarcophagus, a crypt, sepulchre, or ossuary, a mound or barrow, or endlessly monumental surface structures, a mausoleum such as the Taj Mahal. In Tibet, one method of corpse disposal is sky burial, which involves placing the body of the deceased in a high ground (mountain) and dispose it ritually — especially to birds of prey. Sometimes this is because in some religious views, birds of prey are carriers of soul to heaven, but other times, this simply reflect the fact that when terrain (Tibet) makes the ground too hard to dig, there aren't many trees around to burn and the local religion (Buddhism) believes that the body after death is only an empty shell, there are more practical ways of disposing a body, like, for example, leaving it for animals. On the other hand in certain cultures efforts are made to retard the decay processes before burial (resulting even in the retard of decay processes after the burial) , mummification or embalming. This happens during or after a funeral ceremony. Many funeral customs exist in different cultures.

A new alternative is "ecological burial". This involves subsequently deep-freezing, pulverisation by vibration, freeze-drying, removing metals, and burying the resulting powder, which has 30% of the body mass.

Graves are usually grouped together in a plot of land called a cemetery or "graveyard" and can be arranged by a funeral home, mortuary , undertaker or by a church.

[edit]

 

Personification of death

Main article: Death (personification)

Death is also a mythological figure who has existed in popular culture since the earliest days of storytelling. The traditional Western image of Death, known as the Grim Reaper, is employed on a tarot card and in various television shows and films. Some examples:

  • Death is a major character in the Discworld series by Terry Pratchett.
  • An unusual personification of Death appears in Neil Gaiman's Sandman graphic novels.
  • In Ingmar Bergman's The Seventh Seal, a knight plays a game of chess against Death.
  • Death is also portrayed as a Grim Reaper-esque character in TV shows such as Family Guy and video and computer games such as The Sims.
  • In the film, Meet Joe Black, a remake of Death Takes a Holiday, Death inhabits the body of a young man to experience life firsthand.
  • In the film, Bill & Ted's Bogus Journey, Death is the bassist for Wyld Stallyns.
  • In the TV series Dead Like Me, the main characters are all Grim Reapers as part of a post-life bureaucracy.
  • The series Touched by an Angel featured the Angel of Death as a regular character, depicted as a kindly, soft-spoken man in his mid-30s.
  • The Angel of Death also appeared in the show Charmed as a man that appeared before those who had died to take them to the afterlife. He was nor good or evil. Prue Halliwell learned that she could not stop Death in its tracks, no matter how much she tried. She escaped her own fate, however, she was killed a few episodes later by the demon Shax. Later, her sister Piper had to take the role of the Angel of Death and take her own sister Paige to the afterlife, which was avoided when they "fooled" Death by making a trade for Paige's life and that of a demon.
  • Death is also a recurring character in the Castlevania video games. He is usually described as Dracula's servant, and is therefore evil. He is almost always a boss, and appears usually near the end of the game. He uses the scythe, and often transforms into more hideous forms.
[edit]

 

See also

[edit]

External links




Learn More About the Biopharmaceutical Industry and Clinical Research:


Category:

Logo sidebar
  • Analytical Chemistry
  • Bioinformatics
  • Biology
  • Biochemistry
  • Biotechnology
  • Biotechnology Companies
  • Cell Imaging
  • Chemistry
  • Chemists
  • Crystallography
  • Ecology
  • Environmentalism
  • Genetic Engineering
  • Genetically Modified Organisms
  • Genetics
  • Health
  • Health Care
  • Health Sciences
  • Medical Specialities
  • Medicine
  • Molecular Genetics
  • Pharmaceutical Industry
  • Pharmacy
  • Pharmacology

  • Powered by Wikipedia, the free encyclopedia. Articles were developed by IBPA volunteers.

    Logo sidebar

    A

    B

    C

    D

    E

    F

    G

    I

    K

    L

    M

    N

    P

    Q

    R

    S

    T


    Logo sidebar


    IBPA Sponsors and Active Supporters

    http://www.payoneer.com/
    Access Clinical Trials

    Access Clinical Trials
    Access Clinical Trials


    Allied Research International
    Allied Research International

    Altaspera Global Services Inc.
    Altaspera Global Services

    Financial Planning and Personal Insurance
    For Canadian Pharmaceutical Industry Executives


    Biorole Scientific Solutions
    Biorole Scientific Solutions

    CEREPROTEC INC. Development of Novel Neuroprotective Drugs
    CEREPROTEC INC. Development of Novel Neuroprotective Drugs

    Recruitment Advertising Agencies
    Recruitment Advertising Agencies

    Cellular Technology Ltd.
    Cellular Technology Ltd.

    Clinical Trial Network
    Free Database of Clinical Investigators

    ClinQua Clinical Trials Inc.
    ClinQua Clinical Trials Inc.

    Coronis Clinical Research Organization
    Coronis Clinical Research Organization

    CPIC Latin America
    CPIC Latin America

    Espoir Bridge Recruiters
    Espoir Bridge Recruiters

    Genentech
    Genentech

    ILS SA
    Independent Research and Laboratory Solutions

    Inova Health Research
    Inova Health Research, Inc.

    Kriger Research Group International
    Kriger Research Group International

    LCCT
    LCCT

    Metrics Research
    Complete Research Solutions on a Single Platform

    Pharmalef Developments
    Pharmalef Developments

    PrimeHealth Clinical Research Organization
    PrimeHealth Clinical Research Organization

    Research & Development RA SA
    Research & Development RA SA

    Scios Inc.
    Scios Inc. - Manufacturer of Health Care Products

    Scios Inc.
    Southeast Regional Research Group LLC.

    UniMR
    UniMR Clinical Research

    YM BioSciences
    YM BioSciences

    Become IBPA Sponsor
    Post Your Logo Here

    ©2004 International Biopharmaceutical Association Inc., all rights reserved
    Privacy Policy - Terms of Use

    Google